A correlated morphological and functional study of the effects of actinomycin D on HeLa cells. I. Effects on the nucleolar and cytoplasmic ribonucleoproteins.

@article{Clark1967ACM,
  title={A correlated morphological and functional study of the effects of actinomycin D on HeLa cells. I. Effects on the nucleolar and cytoplasmic ribonucleoproteins.},
  author={Allen M Clark and Robert Love and George P. Studzinski and Kay A. O. Ellem},
  journal={Experimental cell research},
  year={1967},
  volume={45 1},
  pages={
          106-19
        }
}
Abstract The sequence of changes in the ribonucleoproteins (RNP) of HeLa cells caused by low levels (0.01 μg/ml) of actinomycin D was studied. Within a few hours the nucleolini enlarged and began to fuse. They assumed a marginal position in the nucleolus at first producing a mulberry appearance, later fusing to form dark-staining “nucleolar caps”. By 16 hr the nucleolar caps either contained no stainable RNA or had disappeared, and the pars amorpha of the nucleolus was diminished in size. After… CONTINUE READING