A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas.

@article{Girling1989ACP,
  title={A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas.},
  author={Anne Girling and Jirina Bartkova and Joy Burchell and Sandra J Gendler and Cheryl E. Gillett and Joyce Taylor-Papadimitriou},
  journal={International journal of cancer},
  year={1989},
  volume={43 6},
  pages={
          1072-6
        }
}
The monoclonal antibody (MAb) SM-3, which was raised to chemically deglycosylated milk mucin, reacts with an epitope present on the core protein of this mucin which we have referred to as PEM (polymorphic epithelial mucin). Although this mucin is abundantly expressed by both the lactating breast and breast carcinomas, the antibody SM-3 shows very little or no reactivity on the former but does react with 92% of breast carcinomas. Furthermore, SM-3 stains primary carcinomas of the lung, colon and… CONTINUE READING

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