A core microRNA signature associated with inducers of the epithelial-to-mesenchymal transition.

@article{DazMartn2014ACM,
  title={A core microRNA signature associated with inducers of the epithelial-to-mesenchymal transition.},
  author={Juan C. D{\'i}az-Mart{\'i}n and Antonio D{\'i}az-L{\'o}pez and Gema Moreno-Bueno and Mar{\'i}a {\'A}ngeles Castilla and Juan Manuel Rosa-Rosa and A Barbado Cano and Jos{\'e} Palacios},
  journal={The Journal of pathology},
  year={2014},
  volume={232 3},
  pages={319-29}
}
Although it is becoming clear that certain miRNAs fulfil a fundamental role in the regulation of the epithelial-to-mesenchymal transition (EMT), a comprehensive study of the miRNAs associated with this process has yet to be performed. Here, we profiled the signature of miRNA expression in an in vitro model of EMT, ectopically expressing in MDCK cells one of seven EMT transcription factors (SNAI1, SNAI2, ZEB1, ZEB2, TWIST1, TWIST2 or E47) or the EMT inducer LOXL2. In this way, we identified a… CONTINUE READING