A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.

@article{Guenther2000ACS,
  title={A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.},
  author={Matthew G. Guenther and William S. Lane and Wolfgang Fischle and Eric Verdin and Mitchell A Lazar and Ramin Shiekhattar},
  journal={Genes & development},
  year={2000},
  volume={14 9},
  pages={1048-57}
}
The corepressor SMRT mediates repression by thyroid hormone receptor (TR) as well as other nuclear hormone receptors and transcription factors. Here we report the isolation of a novel SMRT-containing complex from HeLa cells. This complex contains transducin beta-like protein 1 (TBL1), whose gene is mutated in human sensorineural deafness. It also contains HDAC3, a histone deacetylase not previously thought to interact with SMRT. TBL1 displays structural and functional similarities to Tup1 and… CONTINUE READING
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