A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.

@article{Hakimi2002ACC,
  title={A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.},
  author={Mohamed-Ali Hakimi and Daniel A. Bochar and Josh G. Chenoweth and William S. Lane and Gail Mandel and Ramin Shiekhattar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 11},
  pages={7420-5}
}
BRAF35, a structural DNA-binding protein, initially was identified as a component of a large BRCA2-containing complex. Biochemical analysis revealed the presence of a smaller core-BRAF35 complex devoid of BRCA2. Here we report the isolation of a six-subunit core-BRAF35 complex with the capacity to deacetylate histones, termed the BRAF-histone deacetylase complex (BHC), from human cells. BHC contains polypeptides reminiscent of the chromatin-remodeling complexes SWI/SNF and NuRD (nucleosome… CONTINUE READING
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