A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques.

@article{Lim2010ACR,
  title={A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques.},
  author={Sinchun Lim and Brett M Paterson and Michelle T. Fodero-Tavoletti and Graeme J. O'Keefe and Roberto Cappai and Kevin Jeffrey Barnham and Victor Villemagne and Paul S Donnelly},
  journal={Chemical communications},
  year={2010},
  volume={46 30},
  pages={5437-9}
}
A bis(thiosemicarbazonato)copper(ii) complex with an appended stilbene functional group binds to amyloid-beta plaques that are associated with Alzheimer's disease. The complex has the potential to be of use as a copper-64 radiopharmaceutical to assist in the diagnosis of Alzheimer's disease by positron emission tomography.