A coordinate-based meta-analysis of white matter alterations in patients with alcohol use disorder

  title={A coordinate-based meta-analysis of white matter alterations in patients with alcohol use disorder},
  author={Carolin Spindler and Louisa Mallien and Sebastian Trautmann and Nina C. Alexander and Markus Muehlhan},
  journal={Translational Psychiatry},
Introduction: Besides the commonly described gray matter (GM) deficits, there is growing evidence of significant white matter (WM) alterations in patients with alcohol use disorder (AUD). WM changes can be assessed using volumetric and diffusive magnetic resonance imaging methods, such as voxel-based morphometry (VBM) and diffusion tensor imaging (DTI). The aim of the present meta-analysis is to investigate the spatial convergence of the reported findings on WM alterations in AUD. Methods… 

Association between white matter microstructure and cognitive function in patients with methamphetamine use disorder.

Understanding of white matter microstructure that is related to neurocognitive deficits in MUD was extended and provided potential targets for the prevention and treatment of this chronic disorder.

Alterations in white matter microstructure in alcohol and alcohol‐polydrug dependence: Associations with lifetime alcohol and nicotine exposure

Overall, the findings show that AD is associated with lower FA and suggest that these alterations are primarily driven by lifetime alcohol consumption and cigarette smoking, showing no relationship with exposure to other substances such as cocaine, opiates or cannabis.



Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder

The results suggest that GM reduction in AUD could disrupt network communication responsible for the neurocognitive impairments associated with high chronic alcohol consumption.

White matter volume in alcohol use disorders: a meta‐analysis

The results are suggestive of WM recovery with sustained abstinence and point to the need for further investigation of factors related to treatment‐seeking status and length of abstinence.

Gray and white matter morphology in substance use disorders: a neuroimaging systematic review and meta-analysis

Findings indicate particular brain morphometry alterations in SUDs, which may inform the understanding of disease progression and ultimately therapeutic approaches, using the anatomic likelihood estimation (ALE) method implemented in GingerALE.

Differences in White Matter Microstructure and Connectivity in Nontreatment‐Seeking Individuals with Alcohol Use Disorder

The inverse relationship of entire WM skeleton FA with self-reported alcohol consumption supports previous evidence of a continuum of detrimental effects of alcohol consumption on WM, and provides additional evidence that alcohol dependence is associated with reduced WM integrity in currently drinking NTS alcohol-dependent individuals.

Diffusion tensor imaging of white matter networks in individuals with current and remitted alcohol use disorders and comorbid conditions.

  • M. MonnigA. Caprihan R. Thoma
  • Medicine
    Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
  • 2013
MRI data indicated that AUD-R manifested damage in parietal regions integral to processing of visuospatial information and self-awareness whereas AUD-C showed abnormal diffusivity in fronto-temporal regions that regulate impulsivity, attention, and memory.

Broad disruption of brain white matter microstructure and relationship with neuropsychological performance in male patients with severe alcohol dependence.

These findings provide further evidence for reduced integrity of interhemispheric connections in male patients with severe alcohol dependence, and neurocognitive performance was in part correlated with FA.

A widespread distinct pattern of cerebral atrophy in patients with alcohol addiction revealed by voxel-based morphometry

Evidence is provided that alcohol addiction is associated with altered density of GM and WM of specific brain regions and Voxel-based morphometry is an effective tool for in vivo investigation of cerebral atrophy in patients with alcohol addiction.