A convergent approach to huperzine A and analogues.


We describe a concise and convergent synthesis of (rac)-5-methoxy-6-azatricyclco[,7)]trideca-2(7),3,5,11-tetraen-13-ol, which has the basic ring system of huperzine A, a potent inhibitor of acetylcholinesterase. We also describe the synthesis of the novel system 5-methoxy-6-azatricyclo[,7)]trideca-2(7),3,5-trien-10-one and a series of… (More)


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