A convenient method for regional monoamine oxidase-A determination by [14C]clorgyline autoradiography.

@article{Murakami1992ACM,
  title={A convenient method for regional monoamine oxidase-A determination by [14C]clorgyline autoradiography.},
  author={Matsutaro Murakami and Yasushi Kondoh and Y Weimin and Shigenori Mizusawa and Hiroyuki Nakamichi and Kuniyuki Takahashi and Hiroshi Sasaki and Hidehiro Iida and Shuichi Miura and Iwao Kanno},
  journal={International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology},
  year={1992},
  volume={19 6},
  pages={619-26}
}
The availability of clorgyline for regional monoamine oxidase-A (MAO-A) determination was examined using [14C]clorgyline in rat. [14C]Clorgyline was synthesized by the methylation reaction of N-desmethyl-clorgyline and [14C]methyliodide in dimethylformamide with high radiochemical yield. The MAO-A distribution map by autoradiography correlated with that by histochemical technique and its quantity was consistent with the calculated MAO-A amount based on previous reports. The combination of… CONTINUE READING

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