A convenient formula for sample size calculations in clinical trials with multiple co-primary continuous endpoints.

@article{Sugimoto2012ACF,
  title={A convenient formula for sample size calculations in clinical trials with multiple co-primary continuous endpoints.},
  author={Tomoyuki Sugimoto and Takashi Sozu and Toshimitsu Hamasaki},
  journal={Pharmaceutical statistics},
  year={2012},
  volume={11 2},
  pages={
          118-28
        }
}
The clinical efficacy of a new treatment may often be better evaluated by two or more co-primary endpoints. Recently, in pharmaceutical drug development, there has been increasing discussion regarding establishing statistically significant favorable results on more than one endpoint in comparisons between treatments, which is referred to as a problem of multiple co-primary endpoints. Several methods have been proposed for calculating the sample size required to design a trial with multiple co… CONTINUE READING

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