A controlled trial of lithium augmentation in fluvoxamine-refractory obsessive-compulsive disorder: lack of efficacy.

@article{Mcdougle1991ACT,
  title={A controlled trial of lithium augmentation in fluvoxamine-refractory obsessive-compulsive disorder: lack of efficacy.},
  author={Christopher J. Mcdougle and Lawrence H Price and Wayne K. Goodman and Dennis S. Charney and George R. Heninger},
  journal={Journal of clinical psychopharmacology},
  year={1991},
  volume={11 3},
  pages={
          175-84
        }
}
Two- and 4-week double-blind placebo-controlled trials of lithium augmentation of ongoing fluvoxamine treatment trials were conducted in 20 and 10 patients, respectively, with primary obsessive-compulsive disorder (OCD) who had failed to respond to fluvoxamine alone. Although 2 weeks of double-blind lithium augmentation produced a small but statistically significant reduction in obsessive-compulsive symptoms, most patients did not have a clinically meaningful response. Furthermore, there was no… CONTINUE READING
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