A controlled trial of immediate and delayed closure of myelomeningocele.


Sharrard, Zachary, Lorber and Bruce (1963) in a study offorty children with spina bifida cystica, eighteen of whom survived three months, concluded that “operative closure of myelomeningocele should be regarded as a surgical emergency”. They believed that it was ethically unjustifiable to continue their controlled trial of treatment. Following this paper… (More)


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