A controlled trial of homocysteine lowering and cognitive performance.

  title={A controlled trial of homocysteine lowering and cognitive performance.},
  author={Jennifer A McMahon and Timothy J Green and Clark Murray Skeaff and Robert G Knight and Jim I. Mann and Sheila M. Williams},
  journal={The New England journal of medicine},
  volume={354 26},
BACKGROUND The results of observational studies suggest that plasma homocysteine concentrations are inversely related to cognitive function in older people. Our objective was to test the hypothesis that lowering the plasma homocysteine concentration improves cognitive function in healthy older people. METHODS We conducted a two-year, double-blind, placebo-controlled, randomized clinical trial involving 276 healthy participants, 65 years of age or older, with plasma homocysteine concentrations… CONTINUE READING
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