Corpus ID: 37818386

A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants.

@article{Liggins1972ACT,
  title={A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants.},
  author={Graham C. Liggins and Ross N Howie},
  journal={Pediatrics},
  year={1972},
  volume={50 4},
  pages={
          515-25
        }
}
A controlled trial of betamethasone therapy was carried out in 282 mothers in whom premature delivery threatened or was planned before 37 weeks9 gestation, in the hope of reducing the incidence of neonatal respiratory distress syndrome by accelerating functional maturation of the fetal lung. [...] Key Method Two hundred and thirteen mothers were in spontaneous premature labor. When necessary, ethanol or salbutamol infusions were used to delay delivery while steroid or placebo therapy was given. Delay for at…Expand
PREVENTION OF THE RESPIRATORY DISTRESS SYNDROME IN PREMATURE INFANTS BY ANTEPARTUM GLUCOCORTICOID THERAPY
TLDR
This trial confirms the studies of others that antepartum glucocorticoid can significantly reduce the incidence of RDS in premature infants and shows that the L/S ratio rose sharply to mature values following treatment as soon as 48 hours after beginning of dexamethasone. Expand
A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants, by G. C. Liggins, MB, PhD, FRCOG, and R. N. Howie, MB, MRACP, Pediatrics, 1972;50:515-525.
TLDR
It is concluded that this preliminary evidence justifies additional trials, but that additional work is needed before any new routine procedure is established. Expand
Effect of antepartum glucocorticoid administration upon neonatal respiratory distress syndrome and perinatal infection.
TLDR
Maternal infection was significantly increased in hydrocortisone-treated patients who were delivered vaginally compared with control patients and no similar increase in maternal infection was found with betamethasone or methylprednisolone use. Expand
Intravenous dexamethasone for prevention of neonatal respiratory distress: A prospective controlled study.
TLDR
Intravenous dexamethasone is effective in reducing perinatal mortality from respiratory distress syndrome in premature infants delivered between 28 to 33 weeks' gestation and under 28 weeks, and from 34 to 36 weeks, no difference between treated and control groups was observed. Expand
Prenatal administration of betamethasone for prevention of respiratory distress syndrome.
TLDR
It is confirmed that prenatal glucocorticoid treatment reduces the incidence of RDS and mortality in premature infants, and it is indicated that therapy is more effective when delivery is delayed at least two days, that very small premature infants do not benefit from treatment, and that RDS may be less severe after prenatal exposure to betamethasone. Expand
Injection of corticosteroids into mother to prevent neonatal respiratory distress syndrome.
TLDR
It would appear that the injection of steroids is beneficial in mothers at risk of being delivered of premature infants, however, many questions remain to be answered before this method can be relied upon as therapy for women with premature labor. Expand
Antepartum aminophylline treatment for prevention of the respiratory distress syndrome in premature infants.
TLDR
If the time of rupture of membranes is taken into consideration, a significant decrease in the frequency of IRD following aminophylline administration is noted in the infants, whose mothers had ruptured membranes for more than 24 hours. Expand
Antenatal administration of betamethasone to prevent respiratory distress syndrome in preterm infants: report of a UK multicentre trial
TLDR
Premature rupture of the membranes and maternal hypertension did not seem to contraindicate the use of steroids: there was no increase in maternal or neonatal sepsis nor in stillbirth in hypertensive pregnancies in the steroid group. Expand
Corticosteroid therapy for prevention of respiratory distress syndrome in severe preeclampsia.
TLDR
Antenatal corticosteroid therapy with betamethasone for acceleration of fetal lung maturity is a safe and efficient treatment in patients with severe preeclampsia at between 26 and 34 weeks' gestation. Expand
Maternal corticosteroid and tocolytic treatment and morbidity and mortality in very low birth weight infants.
TLDR
Evidence for the effectiveness of tocolytic therapy to achieve significant improvement in any neonatal outcome such as mortality, RDS, or other neonatal morbidity is less convincing,’ although the use of these agents is common. Expand
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