A controlled trial of acyclovir for chickenpox in normal children.

  title={A controlled trial of acyclovir for chickenpox in normal children.},
  author={Lisa M Dunkle and Ann Margaret Arvin and Richard J. Whitley and Harley A. Rotbart and Henry M. Feder and Sarah Feldman and Anne A. Gershon and Michael L Levy and Gregory F. Hayden and P V McGuirt},
  journal={The New England journal of medicine},
  volume={325 22},
BACKGROUND Chickenpox, the primary infection caused by the varicella-zoster virus, affects more than 3 million children a year in the United States. Although usually self-limited, chickenpox can cause prolonged discomfort and is associated with infrequent but serious complications. METHODS To evaluate the effectiveness of acyclovir for the treatment of chickenpox, we conducted a multicenter, double-blind, placebo-controlled study involving 815 healthy children 2 to 12 years old who contracted… CONTINUE READING


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