A controlled trial of a human papillomavirus type 16 vaccine.

  title={A controlled trial of a human papillomavirus type 16 vaccine.},
  author={Laura A. Koutsky and Kevin A. Ault and Cosette Marie Wheeler and Darron R. Brown and Eliav Barr and Frances B Alvarez and Lisa M Chiacchierini and Kathrin Ute Jansen},
  journal={The New England journal of medicine},
  volume={347 21},
BACKGROUND Approximately 20 percent of adults become infected with human papillomavirus type 16 (HPV-16). Although most infections are benign, some progress to anogenital cancer. A vaccine that reduces the incidence of HPV-16 infection may provide important public health benefits. METHODS In this double-blind study, we randomly assigned 2392 young women (defined as females 16 to 23 years of age) to receive three doses of placebo or HPV-16 virus-like-particle vaccine (40 microg per dose… CONTINUE READING
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