A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection. Infectious Diseases Collaborative Antiviral Study Group.

@article{Whitley1991ACT,
  title={A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection. Infectious Diseases Collaborative Antiviral Study Group.},
  author={Richard J. Whitley and Ann Margaret Arvin and Charles G Prober and Sandra K. Burchett and Lawrence Corey and Dwight A Powell and Stanley Plotkin and Stuart E Starr and Cynthia Alford and James Connor},
  journal={The New England journal of medicine},
  year={1991},
  volume={324 7},
  pages={444-9}
}
BACKGROUND Despite the use of vidarabine, herpes simplex virus (HSV) infection in neonates continues to be a disease of high morbidity and mortality. We undertook a controlled trial comparing vidarabine with acyclovir for the treatment of neonatal HSV infection. METHODS Babies less than one month of age with virologically confirmed HSV infection were randomly and blindly assigned to receive either intravenous vidarabine (30 mg per kilogram of body weight per day; n = 95) or acyclovir (30 mg… CONTINUE READING

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