A controlled study of flumazenil-precipitated withdrawal in chronic low-dose benzodiazepine users

@article{Mintzer1999ACS,
  title={A controlled study of flumazenil-precipitated withdrawal in chronic low-dose benzodiazepine users},
  author={M. Mintzer and K. Stoller and R. Griffiths},
  journal={Psychopharmacology},
  year={1999},
  volume={147},
  pages={200-209}
}
Abstract Rationale: Preclinical studies of the benzodiazepine antagonist flumazenil (Romazicon®) have contributed to the understanding of the physical dependence associated with chronic benzodiazepine use; when administered to animals chronically pretreated with benzodiazepines, flumazenil precipitates a withdrawal syndrome. However, few controlled clinical studies have been conducted. Objectives: The objective was to characterize the effects of flumazenil in long-term users of therapeutic… Expand
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