A controlled study of ACTH therapy in infantile spasms.

  title={A controlled study of ACTH therapy in infantile spasms.},
  author={Richard A. Hrachovy and James D. Frost and Peter Kellaway and Thomas Zion},
  volume={21 6},
A controlled study of 5 patients with infantile spasms was performed to determine the effectiveness of corticotropin (ACTH) treatment. Patients were monitored serially, using a time-synchronized polygraphic and video system. Serum cortisol levels were determined by radioimmunoassay. Four patients showed total cessation of seizures and normalization of the EEG on low-dose ACTH therapy. Two of these patients became hypertensive, requiring discontinuance of ACTH. Serum cortisol levels increased… CONTINUE READING

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