A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic‐resistant Pseudomonas aeruginosa; a preliminary report of efficacy

  title={A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic‐resistant Pseudomonas aeruginosa; a preliminary report of efficacy},
  author={Angela Wright and Catherine Hawkins and Erik E. {\"A}ngg{\aa}rd and David R. Harper},
  journal={Clinical Otolaryngology},
Objectives:  To evaluate the efficacy and safety of a therapeutic bacteriophage preparation (Biophage‐PA) targeting antibiotic‐resistant Pseudomonas aeruginosa in chronic otitis. 
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Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen that is found ubiquitously in the environment. It is also the cause of nosocomial infections, which affects patients with cystic ...
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Bacteriophage formulated into a range of semisolid and solid dosage forms maintain lytic capacity against isolated cutaneous and opportunistic oral bacteria
Research into the development of bacteriophage as therapeutic agents against bacterial infections may help alleviate the problem of resistance of bacteria to antimicrobial agents.
Safety and efficacy of topical bacteriophage and ethylenediaminetetraacetic acid treatment of Staphylococcus aureus infection in a sheep model of sinusitis
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Is biofilm the cause of chronic otitis externa?
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Adjunctive bacteriophage therapy to treat a chronic relapsing periprosthetic joint infection of the knee and chronic osteomyelitis of the femur caused by multidrug-resistant Pseudomonas aeruginosa eradicated the infection, and no side effects to phages were observed.
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Some of the latest research developments on the exploitation of candidate adjuvant therapeutic agents that may act alongside conventional antibiotics as an alternative therapeutic strategy are addressed.
The History and Applications of Phage Therapy in Pseudomonas aeruginosa
Several historical aspects are addressed as well some applications of phage therapy against P. aeruginosa are addressed.


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Bacteriophage prevents destruction of skin grafts by Pseudomonas aeruginosa.
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The recognition that chronic otolaryngologic bacterial infections are biofilm related has been the impetus for the development of new technologies for the study of biofilms and their prevention and treatment.
Treatment of experimental infections of mice with bacteriophages.
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Experimental infections of mice support the view that bacteriophages could be useful in the treatment of human infections caused by antibiotic-resistant strains of bacteria.
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Efforts should be directed toward early detection and prevention of emergence of antibiotic resistance in Pseudomonas aeruginosa, which results in severe adverse outcomes.
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Direct detection of biofilms on MEM biopsy specimens from children with OME and recurrent OM supports the hypothesis that these chronic middle-ear disorders are biofilm-related.
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  • 2007