A contribution to the chemistry of proteids

  title={A contribution to the chemistry of proteids},
  author={F. G. Hopkins and S. Cole},
  journal={The Journal of Physiology},
IN the first part of this communication we described the separation from the tryptic digestion products of casein of a substance capable of giving the glyoxylic (Adamkiewicz) reaction. This substance was found to yield also the tryptophane reaction with halogens. Since Tiedemann and Gmelin2 in 1831 first described the colour reaction given by pancreatic juice when treated with chlorine water, and Claude Bernard3 in 1856 showed that the same reaction could be obtained from the tryptic digestion… Expand
Heteroauxin and the Growth of Escherichia coli
  • E. Ball
  • Biology, Medicine
  • Journal of bacteriology
  • 1938
The possibility that heteroauxin (3-indoleacetic acid) which is produced by bacteria may have a stimulating effect upon the growth of the organism producing it apparently has not been investigated.Expand
Chapter 2 The Carboline Alkaloids
Publisher Summary This chapter describes the alkaloids of Peganum harmala . Many of the polynuclear indole alkaloids contain the carboline (harman) nucleus, but it is concealed in such a manner thatExpand
2 Pyridoxal-Linked Elimination and Replacement Reactions
Publisher Summary The present biosynthetic pathways for amino acids involve the replacement of one β substituent by another through the action of pyridoxal phosphate (PLP)-containing enzymes.Expand
The natural occurrence of a uracil-5-peptide and its metabolic relationship to guanosine-5'-monophosphate.
Ganosine 5′-monophosphate consistently stimulates, by a factor of from 5 to 7 times, the normal production of an unusual pyrimidine derivative in pea seedlings, which is identified as a uracil 5-peptide most probably derived from β-(2,6-dihydroxypyrimidin-5-yl)alanine and containing glycine, arginine, proline and serine. Expand
The crystal structure of Proteus vulgaris tryptophan indole-lyase complexed with oxindolyl-L-alanine: implications for the reaction mechanism.
It is proposed that this creates distortion of the substrate aromatic ring out of plane and moves the substrate upwards on the reaction coordinate towards the transition state, thus reducing the activation energy and accelerating the enzymatic reaction. Expand
Structural Characterization of New Microcystins Containing Tryptophan and Oxidized Tryptophan Residues
Liquid chromatography-mass spectrometry analysis of a tryptophan oxidation experiment demonstrated that tryptopophan-containing microcystins could be converted into oxidized tryPTophan analogs and that low levels of oxidizedtryptophans congeners were present intracellularly in CAWBG11. Expand
Wood, Gunsalus, and Umbreit showed that tryptophanase catalyzed the stoichiometric conversion of tryptophile to indole, pyruvate, and ammonia and required pyridoxal 5-phosphate as a cofactor. Expand
Observations on urinary excretion of indolylacryloyl glycine.
The findings suggest that in those cases urinary indolylacryloyl glycine excretion was caused by some abnormal composition of intestinal flora spreading in families by cross infection. Expand
The results confirm the conclusion, drawn from growth studies, that niacin is needed to permit tryptophan synthesis at a sufficient rate to promote growth. Expand
Phenole, Chinone und die biogene Bildung von Benzolkernen
Micro-organisms have been amongst the organisms of choice, both for the study of the oxidative catabolism of aromatic compounds, and in the elucidation of the biogenesis of benzene nuclei. TheExpand