A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI.

@article{Muhlen2008ACA,
  title={A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI.},
  author={Constantin von zur Muhlen and Nicola R. Sibson and Karlheinz Peter and Sandra J. Campbell and Panop Wilainam and Georges Emile Raymond Grau and Christoph Bode and Robin Paul Choudhury and Daniel C. Anthony},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 3},
  pages={1198-207}
}
Human and murine cerebral malaria are associated with elevated levels of cytokines in the brain and adherence of platelets to the microvasculature. Here we demonstrated that the accumulation of platelets in the brain microvasculature can be detected with MRI, using what we believe to be a novel contrast agent, at a time when the pathology is undetectable by conventional MRI. Ligand-induced binding sites (LIBS) on activated platelet glycoprotein IIb/IIIa receptors were detected in the brains of… CONTINUE READING