A constitutively active form of the protein kinase p90Rsk1 is sufficient to trigger the G2/M transition in Xenopus oocytes.

@article{Gross2001ACA,
  title={A constitutively active form of the protein kinase p90Rsk1 is sufficient to trigger the G2/M transition in Xenopus oocytes.},
  author={Stefan David Gross and Andrea L. Lewellyn and James L. Maller},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 49},
  pages={46099-103}
}
The protein kinase p90(Rsk) has previously been implicated as a key target of the MAPK pathway during M phase of meiosis II in Xenopus oocytes. To determine whether Rsk is a mediator of MAPK for stimulation of the G(2)/M transition early in meiosis I, we sought to generate a form of Rsk that would be constitutively active in resting, G(2) phase oocytes. Initial studies revealed that an N-terminal truncation of 43 amino acids conferred enhanced specific activity on the enzyme in G(2) phase, and… CONTINUE READING

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Promotes the G2/M Transition

J. G. Spivack, R. L. Erikson, J. L. Maller
Mol. Cell. Biol • 1984

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