A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

@article{Shenker1993ACA,
  title={A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty},
  author={Andrew Shenker and Louisa Laue and Shinji Kosugi and John J. Merendino and Takashi Minegishi and Gordon B. Cutler},
  journal={Nature},
  year={1993},
  volume={365},
  pages={652-654}
}
FAMILIAL male precocious puberty (FMPP) is a gonadotropin-independent disorder that is inherited in an autosomal dominant, male-limited pattern1–5. Affected males generally exhibit signs of puberty by age 4. Testosterone production and Ley dig cell hyper-plasia occur in the context of prepubertal levels of luteinizing hormone (LH)3–5. The LH receptor is a member of the family of G-protein-coupled receptors6,7, and we hypothesized that FMPP might be due to a mutant receptor that is activated in… CONTINUE READING
Highly Cited
This paper has 269 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 144 extracted citations

Hyperplasia in glands with hormone excess.

Endocrine-related cancer • 2016
View 7 Excerpts
Highly Influenced

Genetic Models for the Study of Luteinizing Hormone Receptor Function

Front. Endocrinol. • 2015
View 15 Excerpts
Highly Influenced

270 Citations

02040'51'65'81'97'13
Citations per Year
Semantic Scholar estimates that this publication has 270 citations based on the available data.

See our FAQ for additional information.