A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.

@article{Poland2007ACB,
  title={A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.},
  author={Kathryn S Poland and Mohammed Abd Azim and Matthew R Folsom and Richard C Goldfarb and Rizwan Naeem and Christopher T. Korch and Harry A. Drabkin and Robert M Gemmill and Sharon E. Plon},
  journal={Genes, chromosomes & cancer},
  year={2007},
  volume={46 9},
  pages={805-12}
}
Studying the molecular basis of familial renal cell carcinoma (RCC) has allowed identification of novel RCC genes involved in the pathogenesis of both inherited and sporadic RCC. We describe a constitutional balanced t(3;8)(p14;q24.1) translocation found in a brother and sister with bilateral clear cell RCC (CC-RCC) diagnosed in their forties. Consistent with a prior report, we demonstrated by RT-PCR of RNA from lymphoblastoid cells fusion mRNAs derived from the fragile histidine triad (FHIT… CONTINUE READING