A consistent pattern of RIN1 rearrangements in oral squamous cell carcinoma cell lines supports a breakage-fusion-bridge cycle model for 11q13 amplification.

@article{Shuster2000ACP,
  title={A consistent pattern of RIN1 rearrangements in oral squamous cell carcinoma cell lines supports a breakage-fusion-bridge cycle model for 11q13 amplification.},
  author={Mike Shuster and Li Han and Michelle M Le Beau and E Davis and Marek Sawicki and Christa Lese and No Hyun Park and John Colicelli and Susanne M Gollin},
  journal={Genes, chromosomes & cancer},
  year={2000},
  volume={28 2},
  pages={153-63}
}
Gene amplification is a common feature of tumors. Overexpression of some amplified genes plays a role in tumor progression. Gene amplification can occur either extrachromosomally as double-minute chromosomes (dmin) or intrachromosomally in the form of homogeneously staining regions (hsrs). Approximately one-half of our oral squamous cell carcinomas (OSCCs) are characterized by amplification of band 11q13, usually as an hsr located entopically (occurring or situated at the normal chromosomal… CONTINUE READING
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