A conserved ubiquitination pathway determines longevity in response to diet restriction

@article{Carrano2009ACU,
  title={A conserved ubiquitination pathway determines longevity in response to diet restriction},
  author={Andrea C. Carrano and Zheng Liu and Andrew G Dillin and Tony Hunter},
  journal={Nature},
  year={2009},
  volume={460},
  pages={396-399}
}
Dietary restriction extends longevity in diverse species, suggesting that there is a conserved mechanism for nutrient regulation and prosurvival responses. Here we show a role for the HECT (homologous to E6AP carboxy terminus) E3 ubiquitin ligase WWP-1 as a positive regulator of lifespan in Caenorhabditis elegans in response to dietary restriction. We find that overexpression of wwp-1 in worms extends lifespan by up to 20% under conditions of ad libitum feeding. This extension is dependent on… CONTINUE READING
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