A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria.

@article{Campbell2007ACS,
  title={A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria.},
  author={Elizabeth A. Campbell and Roger S. Greenwell and Jennifer R. Anthony and Sheng Wang and Lionel Guan Chuan. Lim and Kalyan Sundar Das and Heidi Sofia and Timothy J. Donohue and Seth A Darst},
  journal={Molecular cell},
  year={2007},
  volume={27 5},
  pages={
          793-805
        }
}
A transcriptional response to singlet oxygen in Rhodobacter sphaeroides is controlled by the group IV sigma factor sigma(E) and its cognate anti-sigma ChrR. Crystal structures of the sigma(E)/ChrR complex reveal a modular, two-domain architecture for ChrR. The ChrR N-terminal anti-sigma domain (ASD) binds a Zn(2+) ion, contacts sigma(E), and is sufficient to inhibit sigma(E)-dependent transcription. The ChrR C-terminal domain adopts a cupin fold, can coordinate an additional Zn(2+), and is… CONTINUE READING
BETA

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 70 CITATIONS

FILTER CITATIONS BY YEAR

2007
2018

CITATION STATISTICS

  • 20 Highly Influenced Citations

  • Averaged 3 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 54 REFERENCES

Similar Papers

Loading similar papers…