A conserved segmental duplication within ELA.

  title={A conserved segmental duplication within ELA.},
  author={Candice L Brinkmeyer-Langford and William Joseph Murphy and Christopher P Childers and Loren C. Skow},
  journal={Animal genetics},
  volume={41 Suppl 2},
The assembled genomic sequence of the horse major histocompatibility complex (MHC) (equine lymphocyte antigen, ELA) is very similar to the homologous human HLA, with the notable exception of a large segmental duplication at the boundary of ELA class I and class III that is absent in HLA. The segmental duplication consists of a ∼ 710 kb region of at least 11 repeated blocks: 10 blocks each contain an MHC class I-like sequence and the helicase domain portion of a BAT1-like sequence, and the… CONTINUE READING
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