A conserved role for retinoid signaling in vertebrate pancreas development

@article{Stafford2004ACR,
  title={A conserved role for retinoid signaling in vertebrate pancreas development},
  author={David B Stafford and Amata Hornbruch and Paul R. Mueller and Victoria E. Prince},
  journal={Development Genes and Evolution},
  year={2004},
  volume={214},
  pages={432-441}
}
Retinoic acid (RA) signaling plays critical roles in the regionalization of the central nervous system and mesoderm of all vertebrates that have been examined. However, to date, a role for RA in pancreas and liver development has only been demonstrated for the teleost zebrafish. Here, we demonstrate that RA signaling is required for development of the pancreas but not the liver in the amphibian Xenopus laevis and the avian quail. We disrupted RA signaling in Xenopus tadpoles, using both a… CONTINUE READING