A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.

@article{ONeill2007ACR,
  title={A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.},
  author={Brian T. O'Neill and Jaetaek Kim and Adam R. Wende and Heather A. Theobald and Joseph M. Tuinei and Jonathan Buchanan and Aili Guo and Vlad G. Zaha and Don K Davis and John C. Schell and Sihem Boudina and Benjamin E Wayment and Sheldon E. Litwin and Tetsuo Shioi and Seigo Izumo and Morris J Birnbaum and E. Dale Abel},
  journal={Cell metabolism},
  year={2007},
  volume={6 4},
  pages={
          294-306
        }
}
Physiological cardiac hypertrophy is associated with mitochondrial adaptations that are characterized by activation of PGC-1alpha and increased fatty acid oxidative (FAO) capacity. It is widely accepted that phosphatidylinositol 3-kinase (PI3K) signaling to Akt1 is required for physiological cardiac growth. However, the signaling pathways that coordinate physiological hypertrophy and metabolic remodeling are incompletely understood. We show here that activation of PI3K is sufficient to increase… CONTINUE READING
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