A conserved region within the Bordetella pertussis autotransporter BrkA is necessary for folding of its passenger domain.

@article{Oliver2003ACR,
  title={A conserved region within the Bordetella pertussis autotransporter BrkA is necessary for folding of its passenger domain.},
  author={David C. Oliver and George Huang and Elena Nodel and Steve Pleasance and R. Castillo Fernandez},
  journal={Molecular microbiology},
  year={2003},
  volume={47 5},
  pages={1367-83}
}
Autotransporter secretion represents a unique mechanism that Gram-negative bacteria employ to deliver proteins to their cell surface. BrkA is a Bordetella pertussis autotransporter protein that mediates serum resistance and contributes to adherence of the bacterium to host cells. BrkA is a 103 kDa protein that is cleaved to form a 73 kDa alpha-domain and a 30 kDa beta domain. The alpha domain, also referred to as the passenger domain, is responsible for the effector functions of the protein… CONTINUE READING
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