A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state

@inproceedings{Malinauskaite2016ACL,
  title={A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state},
  author={Lina Malinauskaite and Saida Said and Caglanur Sahin and Julie Grouleff and Azadeh Shahsavar and Henriette Bjerregaard and Pernille Noer and Kasper Severinsen and Thomas Boesen and Birgit Schi\ott and Steffen Sinning and Poul Nissen},
  booktitle={Nature communications},
  year={2016}
}
Bacterial members of the neurotransmitter:sodium symporter (NSS) family perform Na(+)-dependent amino-acid uptake and extrude H(+) in return. Previous NSS structures represent intermediates of Na(+)/substrate binding or intracellular release, but not the inward-to-outward return transition. Here we report crystal structures of Aquifex aeolicus LeuT in an… CONTINUE READING