A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes

@article{Thornborrow2002ACI,
  title={A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes},
  author={Edward C Thornborrow and Sejal Patel and Anthony E Mastropietro and Elissa M Schwartzfarb and J J Manfredi},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={990-999}
}
Both the human and the mouse bax promoters contain p53 binding sites which are sufficient to confer p53-dependent transcriptional activation in a heterologous setting. Nevertheless in the context of the bax promoter, these sites do not mediate a p53-dependent response, suggesting that bax may not be a direct transcriptional target of p53. Here, data are presented identifying a conserved p53 response element in the first intron of both the human and the murine bax genes. This element both in… CONTINUE READING
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