A conserved function for pericentromeric satellite DNA

@article{Jagannathan2018ACF,
  title={A conserved function for pericentromeric satellite DNA},
  author={Madhav Jagannathan and Ryan Cummings and Yukiko M. Yamashita},
  journal={eLife},
  year={2018},
  volume={7}
}
A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown. Here we provide evidence that pericentromeric satellite DNA, which is often regarded as junk, is a critical constituent of the chromosome, allowing the packaging of all chromosomes into a single nucleus. We show that the multi AT-hook satellite DNA binding… 
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67 Citations

The modular mechanism of chromocenter formation in Drosophila

It is shown that chromocenter formation is mediated by a ‘modular’ network, where interactions between two sequence-specific satellite DNA-binding proteins, D1 and Prod, bound to their cognate satellite DNAs, bring the full complement of chromosomes into the Chromocenter.

Principles and functions of pericentromeric satellite DNA clustering into chromocenters.

Defective Satellite DNA Clustering into Chromocenters Underlies Hybrid Incompatibility in Drosophila

It is shown that ineffective clustering of divergent satellite DNA in the cells of Drosophila hybrids results in chromocenter disruption, associated micronuclei formation and tissue atrophy, and is proposed a unifying framework that explains how the widely observed satellite DNA divergence between closely related species can cause reproductive isolation.

Functional Significance of Satellite DNAs: Insights From Drosophila

This review summarizes the current knowledge concerning satellite functions, the mechanisms of regulation and evolution of satellites, focusing on recent findings in Drosophila, suggesting relevance of the analysis to a wide range of eukaryotic organisms.

Centromere Repeats: Hidden Gems of the Genome

The regulatory activity of satellite DNAs and their neighboring transposable elements in a chromosomal context with a particular emphasis on the integral role of both in centromere function is discussed, to disparage the conventional exemplification of repetitive DNA in the historically-associated context of ‘junk’.

Cross-species incompatibility between a DNA satellite and the Drosophila Spartan homolog poisons germline genome integrity

The observed 359-MH[sim] cross-species incompatibility supports a model under which ostensibly inert repetitive DNA and essential chromosomal proteins must coevolve to preserve germline genome integrity.

Pericentromeric heterochromatin impacts genome compartmentalization and sex chromosome evolution in a fish

It is demonstrated that the pericentromeric heterochromatin (PCH) can cover a considerably large portion of the chromosomes, and when it does so, it drives chromosome compartmentalization; and a new model for the origin and evolution of homomorphic sex chromosomes in fish is proposed.

Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations

Sequence, Chromatin and Evolution of Satellite DNA

Different classes of satellite DNA sequences, their satellite-specific chromatin features, and how these features may contribute to satellite DNA biology and evolution are described.

The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila

A distinct six subunit protein complex containing HMR and LHR is described and the effect of Hmr mutations on complex integrity and function is analysed, suggesting that HMR needs to bring together components of centromeric and pericentromeric chromatin to fulfil its physiological function and to cause hybrid male lethality.
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