A conserved function for pericentromeric satellite DNA
@article{Jagannathan2018ACF, title={A conserved function for pericentromeric satellite DNA}, author={Madhav Jagannathan and Ryan Cummings and Y. Yamashita}, journal={eLife}, year={2018}, volume={7} }
A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown. Here, we provide evidence that pericentromeric satellite DNA, which is often regarded as junk, is a critical constituent of the chromosome, allowing the packaging of all chromosomes into a single nucleus. We show that the multi-AT-hook satellite DNA-binding… CONTINUE READING
Paper Mentions
36 Citations
Functional Significance of Satellite DNAs: Insights From Drosophila
- Biology, Medicine
- Frontiers in Cell and Developmental Biology
- 2020
- 1
- PDF
Heterochromatin-dependent transcription of satellite DNAs in the Drosophila melanogaster female germline
- Biology
- 2020
- 1
- PDF
Intricate structure of the interphase chromocenter revealed by the analysis of a factor involved in species formation
- Biology
- 2018
- PDF
TBP-Related Factor 2 as a Trigger for Robertsonian Translocations and Speciation
- Biology, Medicine
- International journal of molecular sciences
- 2020
- Highly Influenced
- PDF
Novel Insights Into Epigenetic Reprogramming and Destabilization of Pericentromeric Heterochromatin in Cancer
- Biology, Medicine
- Frontiers in Oncology
- 2020
- PDF
Replication-coupled histone H3.1 deposition determines nucleosome composition and heterochromatin dynamics during Arabidopsis seedling development.
- Biology, Medicine
- The New phytologist
- 2019
- 15
References
SHOWING 1-10 OF 67 REFERENCES
Heterochromatin, satellite DNA, and cell function. Structural DNA of eucaryotes may support and protect genes and aid in speciation.
- Medicine
- Science
- 1971
- 43
The molecular basis of the organization of repetitive DNA-containing constitutive heterochromatin in mammals
- Biology, Medicine
- Chromosome Research
- 2016
- 66
Interphase chromosomes in Arabidopsis are organized as well defined chromocenters from which euchromatin loops emanate
- Medicine, Biology
- Proceedings of the National Academy of Sciences of the United States of America
- 2002
- 388
- PDF
Mouse centric and pericentric satellite repeats form distinct functional heterochromatin
- Biology, Medicine
- The Journal of cell biology
- 2004
- 424
- Highly Influential
- PDF
DNA breaks and chromosome pulverization from errors in mitosis
- Biology, Medicine
- Nature
- 2012
- 841
- Highly Influential
A Network of Nuclear Envelope Membrane Proteins Linking Centromeres to Microtubules
- Biology, Medicine
- Cell
- 2008
- 179
Mapping simple repeated DNA sequences in heterochromatin of Drosophila melanogaster.
- Biology, Medicine
- Genetics
- 1993
- 336