• DOI:10.7554/eLife.34122
Corpus ID: 4338970

A conserved function for pericentromeric satellite DNA

@article{Jagannathan2018ACF,
  title={A conserved function for pericentromeric satellite DNA},
  author={Madhav Jagannathan and Ryan Cummings and Y. Yamashita},
  journal={eLife},
  year={2018},
  volume={7}
}

Madhav Jagannathan, Ryan Cummings, Y. Yamashita

Published 2018

Biology, Medicine

eLife

A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown. Here, we provide evidence that pericentromeric satellite DNA, which is often regarded as junk, is a critical constituent of the chromosome, allowing the packaging of all chromosomes into a single nucleus. We show that the multi-AT-hook satellite DNA-binding… CONTINUE READING

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