• DOI:10.1101/245589
Corpus ID: 196660791

A conserved function for pericentromeric satellite DNA

@article{Jagannathan2018ACF,
  title={A conserved function for pericentromeric satellite DNA},
  author={Madhav Jagannathan and Ryan Cummings and Y. Yamashita},
  journal={bioRxiv},
  year={2018}
}

Madhav Jagannathan, Ryan Cummings, Y. Yamashita

Published 2018

Biology

bioRxiv

A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown. Here we provide evidence that pericentromeric satellite DNA, which is often regarded as junk, is a critical constituent of the chromosome, allowing the packaging of all chromosomes into a single nucleus. We show that the multi AT-hook satellite DNA binding… CONTINUE READING

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