A conserved function for pericentromeric satellite DNA

@article{Jagannathan2018ACF,
  title={A conserved function for pericentromeric satellite DNA},
  author={Madhav Jagannathan and Ryan Cummings and Y. Yamashita},
  journal={bioRxiv},
  year={2018}
}
  • Madhav Jagannathan, Ryan Cummings, Y. Yamashita
  • Published 2018
  • Biology
  • bioRxiv
  • A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown. Here we provide evidence that pericentromeric satellite DNA, which is often regarded as junk, is a critical constituent of the chromosome, allowing the packaging of all chromosomes into a single nucleus. We show that the multi AT-hook satellite DNA binding… CONTINUE READING
    2 Citations

    References

    SHOWING 1-10 OF 107 REFERENCES
    The molecular basis of the organization of repetitive DNA-containing constitutive heterochromatin in mammals
    • 66
    Molecular Structure of a Functional Drosophila Centromere
    • 246
    Mouse centric and pericentric satellite repeats form distinct functional heterochromatin
    • 424
    • PDF
    Interphase chromosomes in Arabidopsis are organized as well defined chromocenters from which euchromatin loops emanate
    • 389
    • PDF
    DNA breaks and chromosome pulverization from errors in mitosis
    • 841
    Sequence analysis of a functional Drosophila centromere.
    • 177
    • PDF
    CHROMOTHRIPSIS FROM DNA DAMAGE IN MICRONUCLEI
    • 583