A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene

@article{Schuh1986ACF,
  title={A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Kr{\"u}ppel, a Drosophila segmentation gene},
  author={Reinhard Schuh and Wilhelm K Aicher and Ulrike Gaul and Serge C{\^o}t{\'e} and Anette Preiss and Dieter Maier and Eveline Seifert and Ulrich Nauber and Christian Schr{\"o}der and Rolf Kemler and Herbert Jaeckle},
  journal={Cell},
  year={1986},
  volume={47},
  pages={1025-1032}
}
Krüppel (Kr), a segmentation gene of Drosophila, encodes a protein sharing structural features of the DNA-binding "finger motif" of TFIIIA, a Xenopus transcription factor. Low-stringency hybridization of the Kr finger coding sequence revealed multiple copies of homologous DNA sequences in the genomes of Drosophila and other eukaryotes. Molecular analysis of one Kr-homologous DNA clone identified a developmentally regulated gene. Its product, a finger protein, relates to Kr by the invariant… CONTINUE READING

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