A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

@article{Cordle2008ACF,
  title={A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition},
  author={Jemima Cordle and Steven Johnson and Joyce Zi Yan Tay and Pietro Roversi and Marian B. Wilkin and Beatriz Hernandez de Madrid and Hideyuki Shimizu and Sacha A. Jensen and Pat Whiteman and Boquan Jin and Christina Redfield and Martin Baron and Susan M Lea and Penny A Handford},
  journal={Nature Structural &Molecular Biology},
  year={2008},
  volume={15},
  pages={849-857}
}
The Notch receptor and its ligands are key components in a core metazoan signaling pathway that regulates the spatial patterning, timing and outcome of many cell-fate decisions. Ligands contain a disulfide-rich Delta/Serrate/LAG-2 (DSL) domain required for Notch trans-activation or cis-inhibition. Here we report the X-ray structure of a receptor binding region of a Notch ligand, the DSL-EGF3 domains of human Jagged-1 (J-1DSL-EGF3). The structure reveals a highly conserved face of the DSL domain… CONTINUE READING
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