A conserved docking motif in MAP kinases common to substrates, activators and regulators

@article{Tanoue2000ACD,
  title={A conserved docking motif in MAP kinases common to substrates, activators and regulators},
  author={Takuji Tanoue and Makoto Adachi and Tetsuo Moriguchi and Eisuke Nishida},
  journal={Nature Cell Biology},
  year={2000},
  volume={2},
  pages={110-116}
}
Mitogen-activated protein kinases (MAPKs) are specifically phosphorylated and activated by the MAPK kinases, phosphorylate various targets such as MAPK-activated protein kinases and transcription factors, and are inactivated by specific phosphatases. Recently, docking interactions via the non-catalytic regions of MAPKs have been suggested to be important in regulating these reactions. Here we identify docking sites in MAPKs and in MAPK-interacting enzymes. A docking domain in extracellular… CONTINUE READING