A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases.

@article{Burbelo1995ACB,
  title={A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases.},
  author={Peter D. Burbelo and David N. Drechsel and Alan G Hall},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 49},
  pages={29071-4}
}
Rho, Rac, and Cdc42 are small GTPases that regulate the formation of a variety of actin structures and the assembly of associated integrin complexes, but little is known about the target proteins that mediate their effects. Here we have used a motif-based search method to identify putative effector proteins for Rac and Cdc42. A search of the GenBankTM data base for similarity with the minimum Cdc42/Rac interactive binding (CRIB) region of a potential effector protein p65PAK has identified over… CONTINUE READING
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