A conserved RNA polymerase III promoter required for gammaherpesvirus TMER transcription and microRNA processing.

@article{Diebel2014ACR,
  title={A conserved RNA polymerase III promoter required for gammaherpesvirus TMER transcription and microRNA processing.},
  author={Kevin W. Diebel and David J. Claypool and Linda F van Dyk},
  journal={Gene},
  year={2014},
  volume={544 1},
  pages={8-18}
}
Canonical RNA polymerase III (pol III) type 2 promoters contain a single A and B box and are well documented for their role in tRNA and SINE transcription in eukaryotic cells. The genome of Murid herpesvirus 4 (MuHV-4) contains eight polycistronic tRNA-microRNA encoded RNA (TMER) genes that are transcribed from a RNA pol III type 2-like promoter containing triplicated A box elements. Here, we demonstrate that the triplicated A box sequences are required in their entirety to produce functional… CONTINUE READING
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