A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis

@inproceedings{Wang2015ACR,
  title={A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis},
  author={Chen Wang and Jian-Feng Chang and Hongli Yan and Da-Liang Wang and Yan Liu and Yuanya Jing and Meng Zhang and Yu-Long Men and Dongdong Lu and Xiao-mei Yang and Su Chen and Fang-Lin Sun},
  booktitle={Oncotarget},
  year={2015}
}
Chromatin is a highly organized and dynamic structure in eukaryotic cells. The change of chromatin structure is essential in many cellular processes, such as gene transcription, DNA damage repair and others. Anti-silencing function 1 (ASF1) is a histone chaperone that participates in chromatin higher-order organization and is required for appropriate chromatin assembly. In this study, we identified the E2 ubiquitin-conjugating enzyme RAD6 as an evolutionary conserved interacting protein of ASF1… CONTINUE READING
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