A conserved African swine fever virus IkappaB homolog, 5EL, is nonessential for growth in vitro and virulence in domestic swine.

@article{Neilan1997ACA,
  title={A conserved African swine fever virus IkappaB homolog, 5EL, is nonessential for growth in vitro and virulence in domestic swine.},
  author={J G Neilan and Zhiqiang Lu and Gerald F. Kutish and Laszlo Zsak and Tommy L Lewis and Daniel L Rock},
  journal={Virology},
  year={1997},
  volume={235 2},
  pages={
          377-85
        }
}
An African swine fever virus (ASFV) gene with similarity to the cellular inhibitor of NFkappaB (IkappaB) was described in the pathogenic African isolate Malawi Lil-20/1 (ORF 5EL) and a cell-culture-adapted European virus, BA71V (ORF A238L). Recently, this gene was shown to be a functional IkappaB homolog capable of downregulating NFkappaB-regulated gene expression. This observation suggests the gene may be of significance to aspects of ASFV pathogenesis and virulence in domestic swine by… CONTINUE READING

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