A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

@article{Shaw1986ACA,
  title={A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation},
  author={G. Shaw and R. Kamen},
  journal={Cell},
  year={1986},
  volume={46},
  pages={659-667}
}
  • G. Shaw, R. Kamen
  • Published 1986
  • Biology, Medicine
  • Cell
  • The mRNAs of transiently expressed genes frequently contain an AU-rich sequence in the 3' untranslated region. We introduced a 51 nucleotide AT sequence from a human lymphokine gene, GM-CSF, into the 3' untranslated region of the rabbit beta-globin gene. Our experiments demonstrate that this caused the otherwise stable beta-globin mRNA to become highly unstable in vivo. The instability conferred by the AU sequence in the mRNA was partially alleviated by treatment of the cells with cycloheximide… CONTINUE READING
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