A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses.

@article{Chen2008ACD,
  title={A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses.},
  author={Ming-wei Chen and Ting-Jen Rachel Cheng and Yaoxing Huang and J Y Jan and Shiou-Hwa Ma and Alice Yu and C. -H. Wong and David D. Ho},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 36},
  pages={13538-43}
}
H5N1 influenza viruses have spread extensively among wild birds and domestic poultry. Cross-species transmission of these viruses to humans has been documented in over 380 cases, with a mortality rate of approximately 60%. There is great concern that a H5N1 virus would acquire the ability to spread efficiently between humans, thereby becoming a pandemic threat. An H5N1 influenza vaccine must, therefore, be an integral part of any pandemic preparedness plan. However, traditional methods of… CONTINUE READING

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