A connexin-32 mutation associated with Charcot-Marie-Tooth disease does not affect channel formation in oocytes.

@article{RabadanDiehl1994ACM,
  title={A connexin-32 mutation associated with Charcot-Marie-Tooth disease does not affect channel formation in oocytes.},
  author={C Rabadan-Diehl and Gerhard Dahl and Ralf Werner},
  journal={FEBS letters},
  year={1994},
  volume={351 1},
  pages={90-4}
}
Members of the connexin family differ most in their carboxy-termini, both with respect to sequence and length. In order to assess the contribution of this region to channel function, a series of carboxy-terminal deletion mutants were tested in the paired-oocyte expression system. Connexin-32 can be truncated by 64 amino acids without detectable loss of its known channel properties. Removal of additional amino acids results in a progressive loss of function over a stretch of 4 amino acids. In… CONTINUE READING