A conformational switch controls cell wall-remodelling enzymes required for bacterial cell division.

@article{Yang2012ACS,
  title={A conformational switch controls cell wall-remodelling enzymes required for bacterial cell division.},
  author={Desir{\'e}e C Yang and Kemin Tan and Andrzej Joachimiak and Thomas G Bernhardt},
  journal={Molecular microbiology},
  year={2012},
  volume={85 4},
  pages={768-81}
}
Remodelling of the peptidoglycan (PG) exoskeleton is intimately tied to the growth and division of bacteria. Enzymes that hydrolyse PG are critical for these processes, but their activities must be tightly regulated to prevent the generation of lethal breaches in the PG matrix. Despite their importance, the mechanisms regulating PG hydrolase activity have remained elusive. Here we investigate the control of cell division hydrolases called amidases (AmiA, AmiB and AmiC) required for Escherichia… CONTINUE READING

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