A conformational switch controlling HIV-1 morphogenesis.

  title={A conformational switch controlling HIV-1 morphogenesis.},
  author={Ingolf Gross and Heinz Hohenberg and Thomas Wilk and Klaus Wiegers and Mira A-M Gr{\"a}ttinger and Barbara M{\"u}ller and Stephanie Fuller and Hans Georg Kraeusslich},
  journal={The EMBO journal},
  volume={19 1},
Assembly of infectious human immunodeficiency virus type 1 (HIV-1) proceeds in two steps. Initially, an immature virus with a spherical capsid shell consisting of uncleaved Gag polyproteins is formed. Extracellular proteolytic maturation causes rearrangement of the inner virion structure, leading to the conical capsid of the infectious virus. Using an in vitro assembly system, we show that the same HIV-1 Gag-derived protein can form spherical particles, virtually indistinguishable from immature… CONTINUE READING


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In vitro assembly properties of purified bacterially expressed capsid proteins of human immunodeficiency virus

  • I. Gross, H. Hohenberg, H. G. Kräusslich
  • Eur. J. Biochem.,
  • 1997
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