A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition.

@article{Bayfield2001ACC,
  title={A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition.},
  author={Mark A. Bayfield and Albert E. Dahlberg and Ulrike Schulmeister and Silke Dorner and Andrea Barta},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 18},
  pages={10096-101}
}
The ribosome is a dynamic particle that undergoes many structural changes during translation. We show through chemical probing with dimethyl sulfate (DMS) that conformational changes occur at several nucleotides in the peptidyl transferase center upon alterations in pH, temperature, and monovalent ion concentration, consistent with observations made by Elson and coworkers over 30 years ago. Moreover, we have found that the pH-dependent DMS reactivity of A2451 in the center of the 23S rRNA… CONTINUE READING
53 Citations
2 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 53 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Nature (London) 411, 498–501

  • N. Polacek, M. Gaynor, A. Yassin, A. S. Mankin
  • Bayfield et al. PNAS u August
  • 2001

Principles of Nucleic Acid Structure, ed

  • W. Saenger
  • Charles R. Cantor (Springer,
  • 1984

Similar Papers

Loading similar papers…