A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold.

@article{Yayon1992ACV,
  title={A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold.},
  author={Avner Yayon and Y Zimmer and Gregory H. Shen and Amiel Avivi and Yosef Yarden and David Givol},
  journal={The EMBO journal},
  year={1992},
  volume={11 5},
  pages={1885-90}
}
Binding of cellular growth factors to their receptors constitutes a highly specific interaction and the basis for cell and tissue-type specific growth and differentiation. A unique feature of fibroblast growth factor (FGF) receptors is the multitude of structural variants and an unprecedented degree of cross-reactivity between receptors and their various ligands. To examine receptor-ligand specificity within these families of growth factors and receptors, we used genetic engineering to… CONTINUE READING

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